Bone marrow cellularity assessment using magnetic resonance imaging in children with aplastic anemia

Aplastic anemia is a life-threatening condition characterized by the suppression of all hematopoietic lineages in bone marrow. Empty intertrabecular spaces are replaced adipose tissue. With modern MR techniques for assessing fat fraction, it has become possible to capture these changes. The fraction estimated as ratio signal intensity from sum and water signals. Aim study: assess diagnostic value marrow quantification patients aged < 18 years with aplastic anemia. study was approved Independent Ethics Committee Scientific Council Dmitry Rogachev National Medical Research Center Pediatric Hematology, Oncology Immunology Ministry Healthcare Russian Federation. included 66 participants under years. A control group consisted 33 healthy subjects mean age 13.03 ± 2.83 interest children confirmed diagnosis anemia, 12.31 4.39 carried out at Federation; scanning performed on Philips Achieva 3.0T MRI scanner using mDixon-quant sequence iliac bones lumbar vertebrae. Our results showed that significantly higher than controls. In values L4, L5 vertebrae were 82.62 10.92% 73.52 17.52%, respectively. group, sites 51.04 11.41% 31.43 10.61%, We found significant difference same between groups ( p 0.01). Bone allows detection decreased cellularity compared children.